Product Description
Approved uses/Indications
Pyohex aids in the treatment of superficial dermatitis associated with infections caused by Staphylococcus intermedius in dogs. Antibiotic therapy is recommended for initial control of the infection or where one or more deep pyodermas are present.
Pyohex is formulated to remove dirt and scale, degrease the skin and kill the cutaneous micro-organisms that primarily or secondarily cause dermatitis. Chlorhexidine is an effective antibacterial agent against many Gram-ve and Gram+ve bacteria as well as having anti-fungal activity. It is both bactericidal and bacteriostatic, depending on the concentration used and the organism sensitivity. At bacteriostatic concentrations absorption of the active ingredient onto the cellular membrane adversely affects membrane functions and inhibits growth. At bactericidal concentrations two effects may be seen: at relatively low concentrations lysis of the cell membrane occurs with consequent loss of cytoplasm; at higher concentrations, lethal coagulation of the cytoplasm occurs without cell rupture.
Key Features
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Independent studies have shown that chlorhexidine is the most efficacious antibacterial, especially against Staphylococcus intermedius, when compared to other commonly used antibacterials such as ethyl lactate and benzoyl peroxide1,2.
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The chlorhexidine in Pyohex works by binding to hair and penetrating the follicle via a wicking action down the hair shaft, to eliminate bacteria in situ. Chlorhexidine kills bacteria by disrupting the cell membrane and precipitating the cell contents.
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In vivo studies have revealed that a 3% chlorhexidine solution is the optimum concentration for use as an antibacterial on skin3.
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Pyohex binds strongly to the skin and hair, resulting in a 4 day residual action. As chlorhexidine is poorly absorbed through the skin, Pyohex is very well tolerated.
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Pyohex contains an advanced surfactant base that removes abnormal lipids that occur due to bacterial lipases. Pyohex does not dry or strip the coat of essential lipids needed to prevent transepidermal water loss, a process that promotes infection.
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Pyohex is pH neutral, specifically designed for canine skin.
Product Information
Packaging
Pyohex is a clear, amber liquid, with a slight soapy odour. Active ingredients: chlorhexidine gluconate 30g/L.
Pyohex is available in a 250mL container.
Dosage & Administration
Wet the animal thoroughly with clean water. Apply to the animal at several points and massage into the coat. A sponge assists lathering and penetration of the coat. Allow to stand for 10 minutes and then rinse off with clean water. Repeat twice-weekly until symptoms abate, then weekly, or as directed by your veterinary surgeon. 10mL should be enough to treat a 10kg dog.
Shelf-life of 2 years. Store below 30°C (Room temperature).
Product Warranty
Precautions
For animal treatment only.
Mandatories
Pfizer Animal Health. A division of Pfizer New Zealand Ltd. Level 3, Pfizer House, 14 Normanby Road, Mt Eden, Auckland, New Zealand. Tel: 0800 650 277 0800 650 277 Fax: 0800 628 629. ®Pyohex is a registered trade mark of Dermcare-Vet Pty Ltd. Registered pursuant to the ACVM Act 1997, No A7502. OTC. Active ingredient: chlorhexidine gluconate.
Contact Information
For technical enquiries please phone Pfizer Technical Services on 0800 650 277 0800 650 277.
References
1. Campbell KL et al (1995) Effects of four antibacterial shampoos on surface bacteria of the skin of dogs. Proc ACVD.
2. Bond R Comparison of the clinical and antimicrobial efficacies of a 3% chlorhexidine shampoo (Pyohex) with a 2.5% Benzoyl Peroxide shampoo (Oxydex) for the treatment of microbial dermatitis in basset hounds.
3. Dermcare-Vet data on file.
Vet Information
Dosage & Administration
Wet the animal thoroughly with clean water. Apply to the animal at several points and massage into the coat. A sponge assists lathering and penetration of the coat. Allow to stand for 10 minutes and then rinse off with clean water. Repeat twice-weekly until symptoms abate, then weekly, or as directed by your veterinary surgeon. 10mL should be enough to treat a 10kg dog.
Shelf-life of 2 years. Store below 30°C (Room temperature).
Precautions
For animal treatment only.
Mandatories
Pfizer Animal Health. A division of Pfizer New Zealand Ltd. Level 3, Pfizer House, 14 Normanby Road, Mt Eden, Auckland, New Zealand. Tel: 0800 650 277 0800 650 277 Fax: 0800 628 629. ®Pyohex is a registered trade mark of Dermcare-Vet Pty Ltd. Registered pursuant to the ACVM Act 1997, No A7502. OTC. Active ingredient: chlorhexidine gluconate.
Contact Information
For technical enquiries please phone Pfizer Technical Services on 0800 650 277 0800 650 277.
References
1. Campbell KL et al (1995) Effects of four antibacterial shampoos on surface bacteria of the skin of dogs. Proc ACVD.
2. Bond R Comparison of the clinical and antimicrobial efficacies of a 3% chlorhexidine shampoo (Pyohex) with a 2.5% Benzoyl Peroxide shampoo (Oxydex) for the treatment of microbial dermatitis in basset hounds.
3. Dermcare-Vet data on file.
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